Profhilo Face

What does Profhilo do for the face?

Profhilo is a hyaluronic-acid bioremodeling injectable designed to diffuse through tissue rather than create focal structural volume. In the supplied 2026 case report, two sessions four weeks apart were associated with progressive improvement in skin firmness, hydration, texture, wrinkles, pores, uniformity and contour at 60 days. Because the evidence is a single case report, these findings should be presented as encouraging rather than guaranteed.

Profhilo for the Face in Abu Dhabi : Hydration, Firmness and Skin Bioremodeling

Facial aging is a three-dimensional process involving skin, fat compartments, musculature and bone. At skin level, common changes include loss of elasticity, thinning, texture irregularity and reduced contour definition. Profhilo® is a hyaluronic-acid-based bioremodeling treatment developed primarily to improve skin quality rather than create focal structural volume.

The supplied 2026 Cureus article reports a 57-year-old South American woman treated with two Profhilo sessions four weeks apart, followed by objective three-dimensional VECTRA® assessment. The case documented progressive changes in firmness, hydration, texture, wrinkles, pores, skin uniformity and facial contour.

Evidence Level

This is a single-patient case report without a control group and with short-term follow-up. It illustrates a published protocol and measurable changes but cannot establish how every patient will respond or how long effects will persist.

What Is Profhilo?

The source describes Profhilo as an intradermal medical device composed of hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid produced using NAHYCO® thermal technology without chemical crosslinking reagents.

• 64 mg of hyaluronic acid in a 2 mL syringe in the reported formulation.
• Wide tissue diffusion and extracellular-matrix remodeling.
• High-molecular-weight HA protection with gradual low-molecular-weight HA release.
• Bioremodeling and biostimulation rather than focal structural volumization.

Profhilo vs Dermal Filler

Feature	Profhilo in the source	Structural filler concept
Primary goal	Hydration, firmness, skin quality and bioremodeling	Projection or focal volume restoration
Tissue behavior	High diffusion and homogeneous integration	More localized placement depending on product
Structural support	Source states it does not provide structural support	Selected when structural support is required
Result profile	Natural progressive skin-quality change	Shape/volume change may be more immediate

What May Profhilo Improve?

• Skin Hydration
• Skin Firmness & Elasticity
• Texture & Luminosity
• Wrinkle Appearance
• Pore Appearance
• Skin Color Uniformity
• Malar & mandibular contour definition in the reported case

Baseline Assessment and Treatment Planning

Before treatment, the patient underwent clinical examination and VECTRA® 3D analysis assessing spots, wrinkles, texture, pores, brown spots and erythematous areas. The information was used to support a personalized treatment plan.

The BAP Protocol Used in the Case

The first session used the Bio Aesthetic Points (BAP) protocol. A total of 2 mL was administered, with 1 mL per side of the face. Each point received 0.2 mL, giving five injection points per hemiface.

BAP point described in source	Anatomic description in case report
Zygomatic point	2 cm lateral to the outer canthus
Nasal-base point	1.5 cm from the base along the midpupillary line
Pretragal point	1 cm below the anteroinferior margin of the tragus
Chin point	1.5 cm lateral to the midline
Mandibular-angle point	1 cm above the angle of the mandible

Clinical-Content Note

These coordinates reproduce the published case protocol. They are included for scientific context and should not be presented as self-injection instructions or a universal protocol for every face.

Immediate Recovery After Session One

The report documented mild to moderate erythema and edema, small isolated bruises, and no ischemia, palpable nodules or focal product accumulation. No systemic adverse events were reported.

Results After Two Profhilo Sessions

The second session was performed 30 days after the first using the same application protocol. The patient reported mild pain and satisfactory immediate recovery.

60-Day Follow-Up

At 60 days, the authors reported progressive improvement in skin firmness and elasticity, with contour redefinition particularly in the malar and mandibular regions. The patient reported high satisfaction and no adverse events.

Objective VECTRA® 3D Findings

Comparative VECTRA® 3D analysis at 60 days demonstrated reduction in wrinkles and pores, improved texture and uniformity, and decreases in erythematous and pigmented areas in this single case.

Evidence Interpretation, Safety and Limitations

Source observation	Website-ready interpretation	Limitation
Two sessions four weeks apart	This published protocol was associated with progressive improvement	Not proof that two sessions are optimal for all patients
Improved firmness, hydration and texture	Profhilo may improve overall skin quality	Single case with short follow-up
Reduced wrinkles and pores on VECTRA	Objective 3D analysis documented measurable changes	No control group
Improved malar/mandibular contour	Subtle contour definition was observed	Profhilo is not a structural volumizer
No major adverse event in this case	Treatment was well tolerated in this patient	One case cannot define population-wide safety

Who May Need a Different Strategy ?

The discussion states that Profhilo’s non-crosslinked formulation results in temporary effects and does not provide structural support. The article also recommends caution in patients with systemic or autoimmune conditions because evidence is limited.

• Major structural volume loss may require a different or additional treatment approach
• Systemic or autoimmune conditions require individualized medical assessment
• Evidence in younger patients and special populations remains limited in this report

Potential Side Effects Mentioned in the Source

• Edema
• Bruising
• Nodules
• Delayed inflammatory reactions

In the reported patient, only mild to moderate erythema, edema and isolated bruising were observed, with no significant adverse events.