\u0645\u0646 \u0633\u064a\u062f\u064a\u0631 \u062e\u0637\u0629 \u0627\u0644\u0634\u0642\u064a\u0642\u0629 \u0627\u0644\u0623\u0648\u0633\u0639 \u0625\u0630\u0627 \u0644\u0632\u0645\u062a \u0639\u0644\u0627\u062c\u0627\u062a \u0648\u0642\u0627\u0626\u064a\u0629 \u0623\u0648 \u062d\u0627\u062f\u0629 \u0625\u0636\u0627\u0641\u064a\u0629\u061f<\/li>\n<\/ul>\n\u0647\u0644 \u064a\u0646\u0628\u063a\u064a \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0628\u0648\u062a\u0648\u0643\u0633 \u0644\u0643\u0644 \u0634\u0642\u064a\u0642\u0629\u061f<\/h3>\n
\u0644\u0627\u060c \u0641\u0642\u0627\u0639\u062f\u0629 \u0627\u0644\u0623\u062f\u0644\u0629 \u062a\u062a\u0639\u0644\u0642 \u062a\u062d\u062f\u064a\u062f\u064b\u0627 \u0628\u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646 \u0627\u0644\u0634\u0642\u064a\u0642\u0629 \u0627\u0644\u0645\u0632\u0645\u0646\u0629 \u0648\u0644\u0627 \u064a\u0646\u0628\u063a\u064a \u062a\u0639\u0645\u064a\u0645\u0647\u0627 \u0639\u0644\u0649 \u0643\u0644 \u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u0635\u062f\u0627\u0639 \u0623\u0648 \u0643\u0644 \u0645\u0631\u064a\u0636 \u0628\u0627\u0644\u0634\u0642\u064a\u0642\u0629 \u0627\u0644\u0639\u0631\u0636\u064a\u0629\u060c \u0648\u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u0635\u062d\u064a\u062d \u0645\u062d\u0648\u0631\u064a \u0644\u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0646\u0627\u0633\u0628.<\/p>\n
\u0647\u0644 \u0627\u0644\u0628\u0648\u062a\u0648\u0643\u0633 \u0639\u0644\u0627\u062c \u062d\u0627\u062f \u0644\u0644\u0634\u0642\u064a\u0642\u0629\u061f<\/h3>\n
\u0644\u0627\u060c \u0641\u0627\u0644\u062f\u0648\u0631 \u0627\u0644\u0645\u0639\u062a\u0645\u062f \u0644\u0640 onabotulinumtoxinA \u0647\u0648 \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646 \u0627\u0644\u0634\u0642\u064a\u0642\u0629 \u0627\u0644\u0645\u0632\u0645\u0646\u0629 \u2014 \u0648\u0644\u064a\u0633 \u062d\u0642\u0646\u0629 \u0625\u0633\u0639\u0627\u0641\u064a\u0629 \u0644\u0625\u064a\u0642\u0627\u0641 \u0646\u0648\u0628\u0629 \u0634\u0642\u064a\u0642\u0629 \u0641\u0631\u062f\u064a\u0629 \u0628\u0639\u062f \u0623\u0646 \u062a\u0643\u0648\u0646 \u0642\u062f \u0628\u062f\u0623\u062a.<\/p>\n
\u0627\u0644\u0628\u0648\u062a\u0648\u0643\u0633 \u0648\u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0648\u0642\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0647\u062f\u0641 CGRP<\/h3>\n
\u062a\u0634\u0645\u0644 \u0627\u0644\u062e\u064a\u0627\u0631\u0627\u062a \u0627\u0644\u0648\u0642\u0627\u0626\u064a\u0629 \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u0623\u064a\u0636\u064b\u0627 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0648\u062d\u064a\u062f\u0629 \u0627\u0644\u0646\u0633\u064a\u0644\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0647\u062f\u0641 \u0645\u0633\u0627\u0631 \u0627\u0644\u0628\u0628\u062a\u064a\u062f \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u062c\u064a\u0646 \u0627\u0644\u0643\u0627\u0644\u0633\u064a\u062a\u0648\u0646\u064a\u0646 (CGRP)\u060c \u0644\u0643\u0646 \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0628\u0648\u062a\u0648\u0643\u0633 \u062a\u0627\u0631\u064a\u062e\u064a\u0629 \u0648\u062a\u0631\u0643\u0651\u0632 \u0639\u0644\u0649 \u0627\u0644\u062a\u0637\u0648\u064a\u0631 \u0641\u064a \u0627\u0644\u0645\u0642\u0627\u0645 \u0627\u0644\u0623\u0648\u0644\u060c \u0648\u0644\u0627 \u062a\u0642\u062f\u0651\u0645 \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0628\u0627\u0634\u0631\u0629 \u0645\u0639 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0647\u062f\u0641 CGRP\u060c \u0648\u0644\u0630\u0644\u0643 \u064a\u062a\u0637\u0644\u0628 \u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0639\u0644\u0627\u062c \u062a\u0642\u064a\u064a\u0645\u064b\u0627 \u0633\u0631\u064a\u0631\u064a\u064b\u0627 \u0645\u0646\u0641\u0635\u0644\u064b\u0627 \u0648\u0641\u0631\u062f\u064a\u064b\u0627.<\/p>\n
\u0627\u0644\u0623\u0633\u0626\u0644\u0629 \u0627\u0644\u0634\u0627\u0626\u0639\u0629 \u062d\u0648\u0644 \u0627\u0644\u0628\u0648\u062a\u0648\u0643\u0633 \u0644\u0644\u0634\u0642\u064a\u0642\u0629 \u0627\u0644\u0645\u0632\u0645\u0646\u0629<\/h2>\n\u0645\u0627 \u0627\u0644\u0630\u064a \u064a\u064f\u0639\u062f\u0651 \u0634\u0642\u064a\u0642\u0629 \u0645\u0632\u0645\u0646\u0629\u061f<\/h3>\n
\u062a\u0639\u0631\u064a\u0641 ICHD-3: \u0635\u062f\u0627\u0639 \u0641\u064a 15 \u064a\u0648\u0645\u064b\u0627 \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 \u0634\u0647\u0631\u064a\u064b\u0627 \u0644\u0623\u0643\u062b\u0631 \u0645\u0646 3 \u0623\u0634\u0647\u0631\u060c \u0645\u0639 \u0633\u0645\u0627\u062a \u0627\u0644\u0634\u0642\u064a\u0642\u0629 \u0641\u064a 8 \u0623\u064a\u0627\u0645 \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 \u0634\u0647\u0631\u064a\u064b\u0627.<\/p>\n
\u0647\u0644 \u0627\u0644\u0628\u0648\u062a\u0648\u0643\u0633 \u0645\u0639\u062a\u0645\u062f \u0644\u0644\u0634\u0642\u064a\u0642\u0629 \u0627\u0644\u0645\u0632\u0645\u0646\u0629\u061f<\/h3>\n
\u0646\u0639\u0645\u060c \u0641\u0642\u062f \u0623\u0635\u0628\u062d OnabotulinumtoxinA \u0639\u0627\u0645 2010 \u0623\u0648\u0644 \u062f\u0648\u0627\u0621 \u0648\u0623\u0648\u0644 \u0645\u0646\u062a\u062c \u062d\u064a\u0648\u064a \u064a\u064f\u0639\u062a\u0645\u062f \u062a\u062d\u062f\u064a\u062f\u064b\u0627 \u0644\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646 \u0627\u0644\u0635\u062f\u0627\u0639 \u0641\u064a \u0627\u0644\u0634\u0642\u064a\u0642\u0629 \u0627\u0644\u0645\u0632\u0645\u0646\u0629.<\/p>\n
\u0647\u0644 \u0627\u0633\u062a\u0646\u062f\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0625\u0644\u0649 \u062a\u062c\u0627\u0631\u0628 \u0639\u0634\u0648\u0627\u0626\u064a\u0629\u061f<\/h3>\n
\u0646\u0639\u0645 \u2014 \u062c\u0627\u0621\u062a \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0645\u062d\u0648\u0631\u064a\u0629 \u0645\u0646 \u062f\u0631\u0627\u0633\u062a\u064a PREEMPT \u0645\u062a\u0634\u0627\u0628\u0647\u062a\u064a \u0627\u0644\u062a\u0635\u0645\u064a\u0645 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629\u060c \u0645\u0632\u062f\u0648\u062c\u062a\u064a \u0627\u0644\u062a\u0639\u0645\u064a\u0629 \u0648\u0639\u0634\u0648\u0627\u0626\u064a\u062a\u064a\u0646 \u0648\u0645\u0636\u0628\u0648\u0637\u062a\u064a\u0646 \u0628\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0648\u0647\u0645\u064a \u0648\u0645\u062a\u0639\u062f\u062f\u062a\u064a \u0627\u0644\u0645\u0631\u0627\u0643\u0632.<\/p>\n
\u0643\u0645 \u0634\u062e\u0635\u064b\u0627 \u0634\u0627\u0631\u0643 \u0641\u064a PREEMPT\u061f<\/h3>\n
\u0634\u0645\u0644\u062a PREEMPT I \u0648II \u0645\u0639\u064b\u0627 1,384 \u0628\u0627\u0644\u063a\u064b\u0627 \u0645\u0635\u0627\u0628\u064b\u0627 \u0628\u0627\u0644\u0634\u0642\u064a\u0642\u0629 \u0627\u0644\u0645\u0632\u0645\u0646\u0629.<\/p>\n
\u0647\u0644 \u064a\u0642\u0636\u064a \u0627\u0644\u0628\u0648\u062a\u0648\u0643\u0633 \u0639\u0644\u0649 \u0627\u0644\u0634\u0642\u064a\u0642\u0629 \u062a\u0645\u0627\u0645\u064b\u0627\u061f<\/h3>\n
\u0644\u064a\u0633 \u0628\u0627\u0644\u0636\u0631\u0648\u0631\u0629\u061b \u0641\u0642\u062f \u0631\u0643\u0651\u0632 \u0627\u0644\u0628\u0631\u0646\u0627\u0645\u062c \u0627\u0644\u0633\u0631\u064a\u0631\u064a \u0639\u0644\u0649 \u062a\u0642\u0644\u064a\u0644 \u062a\u0643\u0631\u0627\u0631 \u0623\u064a\u0627\u0645 \u0627\u0644\u0635\u062f\u0627\u0639 \u0648\u0627\u0644\u0639\u0628\u0621 \u0627\u0644\u0639\u0627\u0645\u060c \u0648\u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u0641\u0631\u062f\u064a\u0629 \u062a\u062a\u0641\u0627\u0648\u062a.<\/p>\n
\u0647\u0644 \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u062a\u062d\u0633\u0651\u0646 \u0627\u0644\u0641\u0627\u0626\u062f\u0629 \u0639\u0644\u0649 \u0645\u062f\u0649 \u0639\u062f\u0629 \u062f\u0648\u0631\u0627\u062a\u061f<\/h3>\n
\u0646\u0639\u0645\u060c \u0641\u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u0645 \u064a\u0633\u062a\u062c\u064a\u0628\u0648\u0627 \u0628\u0639\u062f \u0627\u0644\u062f\u0648\u0631\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0623\u0638\u0647\u0631\u0648\u0627 \u062a\u062d\u0633\u0651\u0646\u064b\u0627 \u0630\u0627 \u0645\u0639\u0646\u0649 \u0633\u0631\u064a\u0631\u064a \u0628\u0639\u062f \u0627\u0644\u062f\u0648\u0631\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0623\u0648 \u0627\u0644\u062b\u0627\u0644\u062b\u0629.<\/p>\n
\u0643\u0645 \u0645\u0631\u0629 \u0623\u064f\u0639\u0637\u064a \u0627\u0644\u0639\u0644\u0627\u062c \u0637\u0648\u064a\u0644 \u0627\u0644\u0623\u0645\u062f \u0641\u064a \u062f\u0631\u0627\u0633\u0629 COMPEL\u061f<\/h3>\n
\u0643\u0644 12 \u0623\u0633\u0628\u0648\u0639\u064b\u0627 \u0639\u0644\u0649 \u0645\u062f\u0649 108 \u0623\u0633\u0627\u0628\u064a\u0639\u060c \u0628\u0625\u062c\u0645\u0627\u0644\u064a \u062a\u0633\u0639 \u062f\u0648\u0631\u0627\u062a \u0639\u0644\u0627\u062c.<\/p>\n
\u0647\u0644 \u0628\u0648\u062a\u0648\u0643\u0633 \u0627\u0644\u0634\u0642\u064a\u0642\u0629 \u0647\u0648 \u0646\u0641\u0633\u0647 \u0628\u0648\u062a\u0648\u0643\u0633 \u0627\u0644\u062c\u0628\u0647\u0629\u061f<\/h3>\n
\u0644\u0627\u060c \u0641\u0639\u0644\u0627\u062c \u0627\u0644\u0634\u0642\u064a\u0642\u0629 \u064a\u0633\u062a\u062e\u062f\u0645 \u0646\u0645\u0648\u0630\u062c\u064b\u0627 \u0645\u0648\u062d\u0651\u062f\u064b\u0627 \u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0645\u0648\u0627\u0636\u0639 \u0644\u0644\u0631\u0623\u0633 \u0648\u0627\u0644\u0631\u0642\u0628\u0629\u060c \u0628\u064a\u0646\u0645\u0627 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062a\u062c\u0645\u064a\u0644\u064a \u0647\u062f\u0641 \u0648\u062e\u0637\u0629 \u062d\u0642\u0646 \u0645\u062e\u062a\u0644\u0641\u0627\u0646.<\/p>\n
\u0643\u0645 \u0645\u0648\u0636\u0639 \u062d\u0642\u0646 \u064a\u064f\u0633\u062a\u062e\u062f\u0645\u061f<\/h3>\n
\u064a\u0633\u062a\u062e\u062f\u0645 \u0646\u0645\u0648\u0630\u062c \u0639\u0644\u0627\u062c \u0627\u0644\u0634\u0642\u064a\u0642\u0629 31 \u0625\u0644\u0649 39 \u0645\u0648\u0636\u0639 \u062d\u0642\u0646 \u0639\u0628\u0631 7 \u0639\u0636\u0644\u0627\u062a \u0641\u064a \u0627\u0644\u0631\u0623\u0633 \u0648\u0627\u0644\u0631\u0642\u0628\u0629.<\/p>\n
\u0647\u0644 \u062a\u0639\u0646\u064a \u0648\u062d\u062f\u0627\u062a \u0627\u0644\u0628\u0648\u062a\u0648\u0643\u0633 \u0627\u0644\u0634\u064a\u0621 \u0646\u0641\u0633\u0647 \u0639\u0628\u0631 \u0627\u0644\u0639\u0644\u0627\u0645\u0627\u062a \u0627\u0644\u062a\u062c\u0627\u0631\u064a\u0629\u061f<\/h3>\n
\u0644\u0627\u060c \u0641\u062c\u0631\u0639\u0627\u062a \u0627\u0644\u0648\u062d\u062f\u0627\u062a \u063a\u064a\u0631 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0628\u0627\u062f\u0644 \u0628\u064a\u0646 \u0645\u0646\u062a\u062c\u0627\u062a \u062a\u0648\u0643\u0633\u064a\u0646 \u0627\u0644\u0628\u0648\u062a\u0648\u0644\u064a\u0646\u0648\u0645 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629.<\/p>\n
\u0647\u0644 \u064a\u0639\u0645\u0644 \u0627\u0644\u0628\u0648\u062a\u0648\u0643\u0633 \u0641\u0642\u0637 \u0628\u0625\u0631\u062e\u0627\u0621 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u0645\u0634\u062f\u0648\u062f\u0629\u061f<\/h3>\n
\u0644\u0627\u060c \u0641\u0627\u0644\u0622\u0644\u064a\u0629 \u062a\u0634\u0645\u0644 \u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0627\u0644\u062d\u0633\u0651\u064a\u0629 \u0648\u0634\u0637\u0631 SNAP-25 \u0648\u062a\u0642\u0644\u064a\u0644 \u0625\u0637\u0644\u0627\u0642 \u0627\u0644\u0628\u0628\u062a\u064a\u062f\u0627\u062a \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0648\u0627\u0644\u0646\u0648\u0627\u0642\u0644 \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u0623\u0644\u0645.<\/p>\n
\u0645\u0627 \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0627\u0644\u062a\u064a \u0623\u064f\u0628\u0644\u063a \u0639\u0646\u0647\u0627 \u0639\u0627\u062f\u0629\u064b\u061f<\/h3>\n
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